However, this exciting research field still faces several great challenges. Namely, approaches used so far for screening ideal NADES have been governed by time consuming empirical methods, while systematic investigation in NADES structure-activity relationship, as a backbone for rational design of these solvents, is still lacking. Extension of fundamental research on NADES solvent properties, as well as development of mathematical models as tools for designing ideal NADES for specific purpose becomes an imperative for industrial use of NADES. Based on the stated above the aim of proposed Project is to is to demonstrate the advantages of using NADES as green approach in the biotechnological preparation and formulation of chiral drugs.